Larry E Denton

Title: Innovations by Larry E Denton

Introduction

Larry E Denton is a notable inventor based in Collinsville, IL (US). He has made significant contributions to the pharmaceutical industry, particularly in the formulation of ibuprofen granulations. With a total of five patents to his name, Denton's work has had a considerable impact on the development of effective pharmaceutical compositions.

Latest Patents

One of Denton's latest patents is focused on high ibuprofen content granulations. This granular pharmaceutical composition contains 85 to 99 percent ibuprofen, 0.9 to 15.0 percent binder, and 0.1 to 5.0 percent polyvinylpyrrolidone. The polyvinylpyrrolidone forms a film with a portion of the binder to create agglomerates. The ibuprofen can be fluidized with a portion of the binder in a fluid bed apparatus and sprayed with an aqueous dispersion of polyvinylpyrrolidone and the remainder of the binder. This granulation can then be blended with additional excipients and, optionally, additional active pharmaceutical ingredients for direct compression into tablets.

Career Highlights

Throughout his career, Larry E Denton has worked with prominent companies in the pharmaceutical sector. Notably, he has been associated with Mallinckrodt, Inc. and Mallinckrodt Specialty Chemicals Company. His experience in these organizations has contributed to his expertise in pharmaceutical formulations and innovations.

Collaborations

Denton has collaborated with several professionals in his field, including Anil M Salpekar. These collaborations have likely enriched his work and contributed to the advancements in his patented technologies.

Conclusion

Larry E Denton is a distinguished inventor whose contributions to pharmaceutical innovations, particularly in ibuprofen formulations, have made a significant impact. His patents reflect a commitment to improving pharmaceutical compositions and enhancing their effectiveness.