Company Filing History:
Years Active: 2023-2025
Title: Innovations in Antibiotic Discovery by Kyuho Moon
Introduction
Kyuho Moon is an accomplished inventor based in Princeton, NJ (US). He has made significant contributions to the field of microbiology and antibiotic discovery. With a total of 2 patents, his work focuses on unlocking the potential of cryptic metabolites produced by bacteria.
Latest Patents
Kyuho Moon's latest patents include groundbreaking methods for detecting bioactive cryptic metabolites. His first patent addresses the challenge of silent biosynthetic gene clusters in bacteria, which often go unexamined during bioactivity screening. The method, known as “Bioactivity-HiTES,” allows researchers to activate these silent clusters and screen for new therapeutic leads. This approach has successfully induced cryptic antibiotics in various actinomycete strains, leading to the identification of two new antibiotics: taylorflavins and cebulantin. These compounds show selective activity against Gram-negative bacteria, presenting promising avenues for future research.
His second patent involves a high-throughput transcriptional assay format that utilizes eGFP to monitor secondary metabolite synthesis in Actinomycete bacteria. This innovative method has revealed nearly 20 novel small molecule products, including a new antifungal and several inhibitors of a cysteine protease linked to cancer. The findings from this research have the potential to significantly advance the discovery of cryptic metabolites with valuable bioactivities.
Career Highlights
Kyuho Moon is affiliated with Princeton University, where he conducts his research. His work has garnered attention for its innovative approach to antibiotic discovery and the activation of silent biosynthetic pathways in bacteria.
Collaborations
Kyuho collaborates with esteemed colleagues, including Mohammad R Seyedsayamdost and Fei Xu, who contribute to the advancement of his research initiatives.
Conclusion
Kyuho Moon's innovative work in the field of microbiology and antibiotic discovery highlights the importance of exploring cryptic metabolites. His patents pave the way for new therapeutic leads that could revolutionize the treatment of bacterial infections.