Company Filing History:
Years Active: 1985-2000
Title: Kurt Wuthrich: Innovator in Nuclear Magnetic Resonance Spectroscopy
Introduction:
Kurt Wuthrich, a prominent scientist in the field of nuclear magnetic resonance (NMR) spectroscopy, has made significant contributions to the study of large biological macromolecules. Through his expertise and groundbreaking inventions, Wuthrich has revolutionized the way we analyze the structures and dynamics of complex molecules. This article will explore his key patents and provide insights into his professional journey.
Patents:
1. Transverse relaxation-optimized spectroscopy (TROSY):
One of Wuthrich's latest patents is on a method called Transverse relaxation-optimized spectroscopy (TROSY). This invention allows obtaining NMR correlation spectra for heteronuclear spin systems, particularly large biological macromolecules in solution. By combining radio frequency (rf) pulses with specific properties, Wuthrich successfully reduced line broadening effects caused by transverse relaxation, which previously hindered the study of large molecules.
2. Method for recording two-dimensional nuclear magnetic resonance spectra:
In another notable patent, Wuthrich proposed a method for recording two-dimensional nuclear magnetic resonance spectra. This technique eliminates certain cross peaks that complicate the interpretation of spectrums, providing clearer and more informative results. Wuthrich described two different approaches: varying the interval between pulses during the measurement or inserting a 180-degree pulse at specific intervals. Both methods improve the analysis of complex molecular structures.
Career and Collaborations:
Throughout his career, Wuthrich has worked with renowned companies in the field of NMR technology, including Spectrospin AG and Bruker AG. These collaborations allowed him to explore and refine innovative methodologies in spectroscopy. While working at these companies, Wuthrich collaborated with distinguished scientists such as Richard R Ernst and Slobodan Macura, further advancing the field of NMR spectroscopy.
Conclusion:
Kurt Wuthrich's contributions to nuclear magnetic resonance spectroscopy have revolutionized our understanding of large biological macromolecules. His patents, TROSY and the method for recording two-dimensional NMR spectra, have provided valuable tools for analyzing complex molecular structures. Wuthrich's collaborations and expertise have greatly influenced the field of NMR spectroscopy, making him a prominent figure in the scientific community.