Company Filing History:
Years Active: 1993-1996
Title: Kurt R Gehlsen: Innovator in Cancer Research
Introduction
Kurt R Gehlsen is a prominent inventor based in San Diego, CA, known for his significant contributions to cancer research. He holds 2 patents that focus on innovative methods to inhibit cell migration and adhesion, particularly in malignant cells. His work has implications for understanding and treating cancer more effectively.
Latest Patents
One of his latest patents is titled "Inhibition of cell migration with synthetic peptides." This invention describes a method of inhibiting the invasion of cells through an extracellular membrane by using synthetic Arg-Gly-Asp-containing peptides. Specifically, it provides peptides with the amino acid sequence Arg-Gly-Asp-Thr, including Gly-Arg-Gly-Asp-Thr-Pro, which inhibit the attachment of cells to type I collagen, fibronectin, and vitronectin. Additionally, the invention includes an assay for quantifying the invasive quality of cells by determining the amount of these peptides necessary to prevent cell penetration through an extracellular membrane, such as an amniotic membrane, in vitro.
Another significant patent is "Adhesion receptor for laminin and its use." This invention provides an adhesion receptor for laminin, isolated from cell or tissue extracts and fractionated on an affinity column composed of cell attachment-promoting fragments of laminin. This receptor can be utilized to prepare specific antibodies for analyzing the amount of laminin receptor expressed by cells, with various applications in cellular and tumor biology.
Career Highlights
Kurt R Gehlsen is associated with the La Jolla Cancer Research Foundation, where he continues to advance research in cancer biology. His work has been instrumental in developing new methodologies that enhance our understanding of cell behavior in the context of cancer.
Collaborations
Throughout his career, Kurt has collaborated with notable scientists, including Erkki I Ruoslahti and Michael D Pierschbacher. These collaborations have further enriched his research and contributed to the advancement of cancer treatment methodologies.
Conclusion
Kurt R Gehlsen's innovative work in cancer research, particularly through his patents, showcases his commitment to improving therapeutic strategies against cancer. His contributions are vital in the ongoing battle against this disease, and his research continues to inspire future innovations in the field.