Kuen-Wang Sheu

Title: Kuen-Wang Sheu: Innovator in Pharmaceutical Chemistry

Introduction

Kuen-Wang Sheu is a notable inventor based in Taoyuan Hsien, Taiwan. He has made significant contributions to the field of pharmaceutical chemistry, particularly in the synthesis of important compounds. With a total of 2 patents to his name, Sheu's work has garnered attention for its innovative approaches and practical applications.

Latest Patents

One of Sheu's latest patents is a process for preparing 4-borono-L-phenylalanine. This process involves reacting N-protected (S)-4-halophenylalanine with a boronating agent and an organolithium to create a reaction mixture. The resulting mixture contains N-protected (S)-4-boronophenylalanine, which is crucial for various biochemical applications.

Another significant patent is a method for making donepezil. This method includes mixing E2M, an organic solvent, a weak base, sodium dithionite, and a phase transfer catalyst to create an E2M mixture solution. The solution is then heated, and water is added to obtain a heated E2M aqueous solution with an organic layer. Extracting and condensing this organic layer yields donepezil. Notably, using sodium dithionite as a reducing agent enhances safety compared to traditional methods that utilize hydrogen gas. This innovative approach also reduces costs associated with expensive noble metal catalysts. The method boasts a reaction time of only 60 minutes, achieving a promising yield of over 85%, thereby improving the efficiency and economic value of donepezil production.

Career Highlights

Kuen-Wang Sheu is currently associated with Taiwan Biotech Co., Ltd., where he continues to advance his research and development efforts. His work has not only contributed to the scientific community but has also had a tangible impact on the pharmaceutical industry.

Collaborations

Sheu has collaborated with notable colleagues, including Shu-Fen Huang and Chia-Cheng Shaw. These partnerships have facilitated the exchange of ideas and expertise, further enhancing the quality of their research.

Conclusion

Kuen-Wang Sheu stands out as an innovative inventor in the realm of pharmaceutical chemistry. His patents reflect a commitment to improving synthesis methods and enhancing safety in drug production. Through his work, Sheu continues to make valuable contributions to