Company Filing History:
Years Active: 1999
Title: Krystina Pietrucha: Innovator in Biostable Porous Materials
Introduction
Krystina Pietrucha is a notable inventor based in Lodz, Poland. She has made significant contributions to the field of biomaterials, particularly in the development of biostable porous materials. Her innovative work focuses on enhancing the properties of collagen for use in tissue reconstruction.
Latest Patents
Krystina holds a patent for a biostable porous material comprising composite biopolymers. This invention involves the use of biomaterials like collagen designed as scaffolds for connective tissue reconstruction. The patent details how proteins conjugated with polyethylene glycols (PEGs) can decrease biodegradation rates and immunogenicity. Various concentrations and molecular weights of PEGs were conjugated to collagen materials, which were then subjected to extensive physicochemical assays, collagenase assays, fibroblast cell cultures, and subcutaneous implantation studies. The results demonstrated that PEG-conjugation significantly delayed degradation by collagenase and maintained normal fibroblast morphology in culture. In vivo studies showed that the porous structure of non-modified sponges collapsed by day 15, while PEG-modified collagen sponges retained their structure for at least 30 days. This research concludes that PEGs conjugated onto collagen sponges stabilize the porous structure without compromising the biological properties of collagen.
Career Highlights
Krystina Pietrucha is affiliated with Université Laval, located in the Cité Universitaire. Her work has been instrumental in advancing the understanding of composite biomaterials and their applications in medical science.
Collaborations
She has collaborated with notable colleagues, including Charles J. Doillon and René C. Gaudreault, contributing to the advancement of research in her field.
Conclusion
Krystina Pietrucha's innovative work in biostable porous materials represents a significant advancement in biomaterials science. Her contributions have the potential to enhance tissue engineering and regenerative medicine.
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