Company Filing History:
Years Active: 2025
Title: Kristen Kozielski: Innovator in Bioreducible Polymers for siRNA Delivery
Introduction
Kristen Kozielski is a prominent inventor based in Baltimore, MD (US). She has made significant contributions to the field of biochemistry and materials science, particularly in the development of innovative polymers for drug delivery systems. Her work focuses on creating materials that enhance the efficacy of therapeutic agents, especially in the context of gene therapy.
Latest Patents
Kristen Kozielski holds a patent for "Bioreducible poly (beta-amino ester)s for siRNA delivery." This patent describes the synthesis of degradable polymers that self-assemble with nucleic acids, proteins, hydrophobic drugs, and other small molecules. These polymers form particles that are effective for delivery into cells, tissues, and organisms, both in vitro and in vivo. The disclosed polymers exhibit differential cell-type specificity and promote endosomal escape, protecting the cargos from degradation and enhancing delivery to the cytoplasm. Additionally, their bioreducibility allows for triggered intracellular drug release, optimizing delivery to target cell types. These materials have potential applications in treating various conditions, including cancer, cardiovascular diseases, infectious diseases, and ophthalmic diseases.
Career Highlights
Kozielski's career is marked by her innovative research and dedication to advancing drug delivery technologies. Her work at Johns Hopkins University has positioned her as a leader in the field, contributing to the development of cutting-edge solutions for complex medical challenges.
Collaborations
Throughout her career, Kristen has collaborated with esteemed colleagues, including Jordan J Green and Stephany Yi Tzeng. These partnerships have fostered a collaborative environment that enhances the research and development of new therapeutic strategies.
Conclusion
Kristen Kozielski's contributions to the field of bioreducible polymers for siRNA delivery exemplify her commitment to innovation in drug delivery systems. Her work not only advances scientific knowledge but also holds promise for improving treatment options for various diseases.