Company Filing History:
1 out of 222 
1 out of 11 Years Active: 2015
Title: Koji Tsuta: Innovator in Cancer Treatment Assessment
Introduction
Koji Tsuta is a prominent inventor based in Tokyo, Japan. He has made significant contributions to the field of cancer research, particularly in developing methods to assess the effectiveness of cancer treatments. His innovative approach focuses on genetic indicators that can predict treatment outcomes for patients.
Latest Patents
Koji Tsuta holds a patent for a method that determines the effectiveness of cancer treatment by assessing the presence of a KIF5B-RET chimeric gene. This method aims to identify a gene that serves as an indicator for predicting the effectiveness of drug treatments targeting lung adenocarcinomas. Through whole-transcriptome sequencing, Tsuta identified in-frame fusion transcripts between the KIF5B gene and the RET gene. His findings revealed that KIF5B-RET gene fusions were present in 6 out of 319 (2%) lung adenocarcinoma specimens from Japanese individuals and 1 out of 80 (1%) specimens from U.S. individuals. Notably, none of the subjects exhibited known activating mutations such as EGFR, KRAS, or ALK oncogenes, indicating that these gene fusions are responsible mutations for oncogenesis. The research suggests that treatments with RET tyrosine kinase inhibitors are effective for patients with these gene fusions.
Career Highlights
Throughout his career, Koji Tsuta has worked with esteemed organizations, including the National Cancer Center and Lsip, LLC. His work has been pivotal in advancing the understanding of genetic factors in cancer treatment, contributing to more personalized and effective therapeutic strategies.
Collaborations
Koji Tsuta has collaborated with notable professionals in the field, including Takashi Kohno. Their joint efforts have furthered research in cancer genetics and treatment efficacy.
Conclusion
Koji Tsuta's innovative work in cancer treatment assessment through genetic indicators highlights the importance of personalized medicine. His contributions are paving the way for more effective cancer therapies and improving patient outcomes.