Kevin T Madden

Title: Kevin T Madden: Innovator in G-Protein Coupled Receptor Research

Introduction

Kevin T Madden is a notable inventor based in Charlestown, MA (US). He has made significant contributions to the field of biochemistry, particularly in the area of G-protein coupled receptors. With a total of 2 patents to his name, Madden's work has implications for drug discovery and therapeutic development.

Latest Patents

Madden's latest patents focus on an assay for agents that alter G-protein coupled receptor activity. The invention describes a novel transformed yeast cell that includes a first heterologous nucleic acid sequence encoding a G-protein coupled receptor and a second nucleic acid sequence encoding the yeast Gα subunit protein Gpa2. An optional third heterologous nucleic acid sequence encoding a reporter protein may also be included. This transformed yeast cell can bind ligands, thereby altering the activity of Gpa2 and influencing cellular levels of second messenger molecules, ultimately affecting the activity of target genes. The yeast cell can be utilized in in vitro high-throughput assays to screen for both agonists and antagonists of G-protein coupled receptor ligand activity.

Career Highlights

Kevin T Madden is currently employed at Millennium Pharmaceuticals Limited, where he continues to advance his research in the field. His work is pivotal in understanding the mechanisms of G-protein coupled receptors, which are crucial for various physiological processes.

Collaborations

Madden collaborates with esteemed colleagues such as Patrick R Errada and Carlos J Gimeno, contributing to a dynamic research environment that fosters innovation and discovery.

Conclusion

Kevin T Madden's contributions to the field of G-protein coupled receptor research highlight his role as an influential inventor. His patents and ongoing work at Millennium Pharmaceuticals Limited underscore the importance of his research in advancing therapeutic applications.