Keren Byrne

Title: Keren Byrne: Innovator in Protein Characterization

Introduction

Keren Byrne is a notable inventor based in St. Lucia, Australia. He has made significant contributions to the field of protein characterization, particularly through his innovative patent. His work focuses on developing methods that enhance the analysis of proteins, which is crucial for various applications in biotechnology and nutrition.

Latest Patents

Keren Byrne holds a patent for "LC-MS/MS-based methods for characterizing proteins." This patent describes methods to analyze the in vitro stability of recalcitrant or membrane-bound proteins in simulated gastric fluid (SGF) that includes the proteolytic enzyme, pepsin. The invention employs a novel pepsin-trypsin assay combined with advanced mass spectrometric techniques, such as LC-MS/MS, to monitor precise degradation products. The methods allow for the evaluation of protein digestion by observing the appearance of peptic products and the disappearance of tryptic peptide products, serving as a proxy for intact protein. Additionally, the patent provides high-sensitivity LC-MRM-MS quantification methods for protein quantitation, which are particularly useful for characterizing proteins produced in transgenic plants, such as canola engineered to produce long-chain omega-3 polyunsaturated fatty acids.

Career Highlights

Throughout his career, Keren has worked with prominent organizations, including Nuseed Nutritional Australia Pty Ltd and the Commonwealth Scientific and Industrial Research Organisation. His experience in these institutions has allowed him to apply his innovative methods in real-world applications, contributing to advancements in nutritional science and biotechnology.

Collaborations

Keren has collaborated with esteemed colleagues, including Susan MacIntosh and Michelle Colgrave. These partnerships have fostered a collaborative environment that enhances research and development in protein characterization.

Conclusion

Keren Byrne's contributions to the field of protein characterization through his innovative patent and collaborative efforts highlight his role as a significant inventor in biotechnology. His work continues to influence advancements in the analysis of proteins, paving the way for future innovations in the industry.