Location History:
- Sakai, JP (1995 - 1996)
- Osaka, JP (1998)
Company Filing History:
Years Active: 1995-1998
Title: Kazumi Amatsu: Innovator in Glutamine Derivatives
Introduction
Kazumi Amatsu is a notable inventor based in Sakai, Japan. He has made significant contributions to the field of biochemistry, particularly in the production of glutamine derivatives. With a total of 3 patents to his name, Amatsu's work has implications for the pharmaceutical industry.
Latest Patents
One of Amatsu's latest patents is a process for producing N-chloroacetylglutamine. This compound is synthesized by reacting chloroacetyl chloride with an alkaline aqueous solution of glutamine in the presence of a water-immiscible organic solvent. The process involves separating the aqueous layer through liquid-liquid separation and crystallizing N-chloroacetyl-glutamine from the aqueous layer under acidic conditions. This innovative method allows for the efficient and cost-effective production of N-chloroacetyl-glutamine, which serves as an intermediate for producing glycyl-L-glutamine, a compound known for its higher stability compared to L-glutamine and its use in infusion solutions.
Another significant patent by Amatsu is the process for producing alanylglutamine. This process involves reacting an N-(2-substituted)-propionylglutamine compound with ammonia at a temperature of 60 degrees Celsius or below. The method ensures the production of highly purified alanylglutamine in high yield without racemization, showcasing Amatsu's commitment to advancing biochemistry.
Career Highlights
Kazumi Amatsu is associated with Kyowa Hakko Kogyo Co., Ltd., a company known for its focus on biotechnology and pharmaceuticals. His work has contributed to the company's reputation as a leader in the production of amino acids and their derivatives.
Collaborations
Amatsu has collaborated with notable coworkers, including Yoshiyuki Yamada and Shoichi Mizutaki. Their combined expertise has furthered the development of innovative processes in the field of biochemistry.
Conclusion
Kazumi Amatsu's contributions to the production of glutamine derivatives highlight his role as an influential inventor in the biochemistry sector. His innovative processes not only enhance the efficiency of production but also contribute to advancements in pharmaceutical applications.