Kazuma Okubo

Title: Kazuma Okubo: Innovator in Recombinant Decarbamylases

Introduction

Kazuma Okubo is a notable inventor based in Kakogawa, Japan. He has made significant contributions to the field of biotechnology, particularly in the production of D-.alpha.-amino acids through innovative methods.

Latest Patents

Kazuma Okubo holds a patent for "Recombinant decarbamylases for producing D-.alpha.-amino acids." This invention involves decarbamylases capable of hydrolyzing N-carbamyl-D-.alpha.-amino acids to produce D-.alpha.-amino acids. The decarbamylases are derived from recombinant microorganisms created through gene manipulation techniques. His work emphasizes the development of decarbamylases with enhanced thermostability, achieved by mutating specific DNA fragments that encode natural decarbamylases. The resulting recombinant DNA is utilized to generate transformants that produce these thermostable enzymes. Furthermore, the decarbamylases can be immobilized in various forms, allowing for repeated use, especially when combined with antioxidants like dithiothreitol.

Career Highlights

Kazuma Okubo is associated with Kanegafuchi Kagaku Kogyo Kabushiki Kaisha, where he has been instrumental in advancing research and development in his field. His innovative approach has led to breakthroughs that enhance the efficiency of amino acid production.

Collaborations

He has collaborated with notable colleagues, including Yasuhiro Ikenaka and Hirokazu Nanba, contributing to the collective expertise and advancements in their research endeavors.

Conclusion

Kazuma Okubo's work in recombinant decarbamylases showcases his commitment to innovation in biotechnology. His contributions are paving the way for more efficient production methods in the field of amino acids.