Company Filing History:
Years Active: 2001
Title: Innovations in Gene Replacement Therapy by Kathleen H Holt
Introduction
Kathleen H Holt is a prominent inventor based in Coralville, IA (US). She has made significant contributions to the field of gene therapy, particularly in the treatment of muscular dystrophy. Her innovative work focuses on developing methods to address sarcoglycan-deficient limb-girdle muscular dystrophy, a condition that affects muscle function.
Latest Patents
Kathleen H Holt holds a patent for a groundbreaking method of gene replacement therapy aimed at treating patients suffering from sarcoglycan-deficient limb-girdle muscular dystrophy. This patent describes a technique that produces extensive long-term expression of the sarcoglycan species, which is crucial for restoring the entire sarcoglycan complex. The therapy results in the stable association of alpha-dystroglycan with the sarcolemma, effectively eliminating the morphological markers associated with the disease. Additionally, her invention includes methods for determining specific defective sarcoglycan species in patient tissue, utilizing cultured muscle cells and expression vectors.
Career Highlights
Kathleen H Holt is affiliated with the University of Iowa Research Foundation, where she continues her research and development in gene therapy. Her work has the potential to significantly impact the treatment of muscular dystrophy, providing hope for patients affected by this debilitating condition.
Collaborations
Throughout her career, Kathleen has collaborated with notable colleagues, including Kevin P Campbell and Franck Duclos. These partnerships have enhanced her research efforts and contributed to the advancement of gene therapy techniques.
Conclusion
Kathleen H Holt's innovative work in gene replacement therapy represents a significant advancement in the treatment of muscular dystrophy. Her contributions to the field are paving the way for new therapeutic approaches that could improve the lives of many patients.