Company Filing History:
Years Active: 2000
Title: Katharine Kramer: Innovator in Enzyme Engineering
Introduction
Katharine Kramer is a prominent inventor based in Madison, WI (US). She has made significant contributions to the field of enzyme engineering, particularly in the development of novel isoforms of the enzyme glutathione S-transferase. Her work has implications for cancer therapeutics, showcasing her commitment to advancing medical science.
Latest Patents
Katharine Kramer holds 1 patent for her innovative method related to glutathione S-transferase isoforms. The patent describes a method for creating novel isoforms of the enzyme that exhibit enhanced activity in host cells against specific toxic agents. This method involves site-directed mutagenesis and selection with the targeted agent in host cells. The site of directed mutagenesis is the site of electrophile binding by the native form of the enzyme, which has proven to be manipulable without losing enzymatic activity. Various techniques for enhancing the expression, activity, or localization of the expressed enzyme in mammalian cells are also detailed. The genes for the mutant isoforms may be particularly useful in cancer therapeutics, providing selected groups of cells with heightened resistance to antineoplastic agents.
Career Highlights
Katharine Kramer is associated with the Wisconsin Alumni Research Foundation, where she continues to pursue her research and innovation in enzyme engineering. Her work is characterized by a strong focus on practical applications that can lead to significant advancements in medical treatments.
Collaborations
Katharine has collaborated with notable colleagues, including William E. Fahl and Andrew M. Gulick. These collaborations have likely contributed to the depth and impact of her research in the field.
Conclusion
Katharine Kramer is a trailblazer in the field of enzyme engineering, with her innovative patent on glutathione S-transferase isoforms paving the way for advancements in cancer therapeutics. Her contributions reflect a dedication to improving health outcomes through scientific innovation.