Company Filing History:
Years Active: 1999
Title: The Innovative Contributions of Karen Duff in Alzheimer’s Research
Introduction
Karen Duff, a notable inventor based in Tampa, Florida, has made significant contributions to the field of Alzheimer's disease research. As a leading researcher at the University of South Florida, her work focuses on developing transgenic animal models that provide a deeper understanding of the pathology associated with Alzheimer's disease.
Latest Patents
Duff holds a patent titled "Transgenic mice expressing APPK670N,M671L and a mutant presenilin - A method of preparing a transgenic animal model with enhanced, accelerated pathology for Alzheimer's Disease (AD)." This groundbreaking patent outlines a method for producing a transgenic animal model that exhibits enhanced pathology for Alzheimer's disease. The method includes generating an F1 generation from two different transgenic parents, each carrying distinct expressible transgenes associated with AD pathology. The resulting offspring are carefully screened to select those that demonstrate an accelerated form of Alzheimer’s pathology, specifically focusing on amyloid accumulation. This innovative approach utilizes a mutant presenilin transgene, along with a transgene for a mutant amyloid precursor protein, optimizing the model for research.
Career Highlights
Karen Duff's career has been marked by her dedication to Alzheimer’s research and finding effective models for studying the disease. Her expertise in genetics and transgenic technology has made her a valuable asset to the research community. The patent granted to her is a testament to her innovative approach and commitment to advancing our understanding of Alzheimer’s pathology.
Collaborations
Throughout her career, Duff has collaborated with esteemed colleagues, including John A. Hardy. These collaborations have focused on exploring new avenues for Alzheimer’s disease research and leveraging their collective knowledge and expertise to develop effective models for investigation and potential treatment development.
Conclusion
Karen Duff's contributions to Alzheimer's research are significant and promising. With her innovative transgenic models, she is paving the way for enhanced understanding and potential therapies for this challenging disease. Her collaboration with other experts in the field further strengthens the impact of her work, making her a key figure in the ongoing battle against Alzheimer’s disease.