Location History:
- Kanagawa, JP (1998 - 2000)
- Odawara, JP (2000 - 2002)
Company Filing History:
5 out of 382 
1 out of 90 Years Active: 1998-2002
Title: Innovations in Protein Production: The Contributions of Kaoru Aoyagi
Introduction
Kaoru Aoyagi is a prominent inventor based in Odawara, Japan. He has made significant contributions to the field of biotechnology, particularly in the mass production of proteins and peptides. With a total of 5 patents to his name, Aoyagi's work has advanced the understanding and application of microbial systems in protein production.
Latest Patents
Aoyagi's latest patents focus on innovative systems for the mass production of proteins or peptides using microorganisms of the genus Humicola. One notable patent describes an expressing system that enables the large-scale production of proteins, particularly cellulase NCE4, at a rate of approximately 4.5 grams or more per liter of culture. This system utilizes an expression vector that incorporates regulatory sequences from the cellulase NCE1 and NCE2 genes. Another patent highlights a high-yield production system for proteins and peptides, specifically targeting cellulase production in filamentous fungi. This system employs the regulator sequence of cellulase cbh1 genes derived from Trichoderma viride, achieving a remarkable production of 15 grams per liter of an endoglucanase.
Career Highlights
Throughout his career, Aoyagi has worked with notable companies, including Meiji Seika Kaisha, Ltd. and Japan as represented by the Director General of the Agency of Industrial Science. His expertise in biotechnology has positioned him as a key figure in the development of efficient protein production systems.
Collaborations
Aoyagi has collaborated with esteemed colleagues, including Takeshi Murakami and Naomi Sumida. These partnerships have fostered innovation and contributed to the advancement of biotechnological research.
Conclusion
Kaoru Aoyagi's contributions to the field of protein production through his innovative patents and collaborations have significantly impacted biotechnology. His work continues to inspire advancements in microbial systems for efficient protein synthesis.