Jyothi Karangula

Title: The Innovative Contributions of Jyothi Karangula

Introduction

Jyothi Karangula is a notable inventor based in Andhra Pradesh, India. He has made significant contributions to the field of chemistry, particularly in the synthesis of pharmaceutical compounds. His work is characterized by a focus on improving processes that enhance the efficiency and effectiveness of drug development.

Latest Patents

Karangula holds a patent for a process titled "Process for preparing taxol side chain using heterogeneous trifunctional catalyst." This invention relates to an improved method for synthesizing (2R,3S)-2,3-dihydroxy-3-phenylpropionate with over 99% enantioselectivity. The process is notable for being devoid of osmium, even in crude form, and utilizes recyclable multifunctional catalysts. The method involves converting the diol obtained without further crystallization into bromoacetate, followed by a reaction with NaN in an organic solvent. This is succeeded by deacetylation to obtain azido alcohol, which is then benzoylated and hydrogenated to yield the (2R,3S)-(N-)-benzoyl-3-phenylisoserine methyl ester in a 67% yield.

Career Highlights

Karangula is affiliated with the Council of Scientific & Industrial Research, where he continues to advance his research and development efforts. His work has not only contributed to the scientific community but has also paved the way for potential advancements in pharmaceutical applications.

Collaborations

He has collaborated with notable colleagues such as Boyapati Manoranjan Choudary and Naidu Sreenivasa Chowdari. These collaborations have further enriched his research endeavors and have fostered a productive environment for innovation.

Conclusion

Jyothi Karangula's innovative work in the synthesis of pharmaceutical compounds exemplifies the impact of dedicated research in the field of chemistry. His contributions are significant and continue to influence advancements in drug development.