Justin Gregory English

Title: Justin Gregory English: Innovator in G Protein-Coupled Receptor Screening Systems

Introduction

Justin Gregory English is a notable inventor based in Chapel Hill, NC (US). He has made significant contributions to the field of biochemistry, particularly in the development of innovative screening systems for G protein-coupled receptors (GPCRs). His work has implications for understanding complex cellular signaling pathways.

Latest Patents

Justin holds a patent for a G protein-coupled receptor screening system. This patent describes an assay platform that includes two complementary systems designed to equate dynamic intermolecular interactions between a receptor and transducer with more complex stimulus-response cascades in living cells. The in vitro ADSoRB method disclosed in his patent allows for the forced dissociation of transducers, such as G protein heterotrimers, from receptors. This process alters receptor conformations and ligand interactions, simulating pathway activation in a cell. Additionally, the TRUPATH method measures the extent of engineered G protein heterotrimer complex dissociation, providing single transducer resolution within a cell.

Career Highlights

Justin is affiliated with the University of North Carolina at Chapel Hill, where he continues to advance research in his field. His innovative approaches to GPCR screening systems have positioned him as a key figure in biochemistry and pharmacology.

Collaborations

He has collaborated with notable colleagues, including Ryan Strachan and Reid Olsen, contributing to a dynamic research environment that fosters innovation and discovery.

Conclusion

Justin Gregory English is a pioneering inventor whose work on G protein-coupled receptor screening systems is shaping the future of biochemical research. His contributions are vital for advancing our understanding of cellular signaling mechanisms.