Junsen Tong

Title: Innovations of Junsen Tong in Cocaine Esterase Mutants

Introduction

Junsen Tong is a notable inventor based in Hangzhou, China. He has made significant contributions to the field of biochemistry, particularly in the development of cocaine esterase mutants. His work aims to improve the catalytic efficiency of enzymes that can potentially mitigate the effects of cocaine toxicity.

Latest Patents

Junsen Tong holds a patent for a cocaine esterase mutant and its applications. The patent, titled "Cocaine esterase mutant and use thereof," discloses a mutant obtained by mutating a wildtype cocaine esterase. The amino acid sequence of the wildtype cocaine esterase is shown as SEQ ID No. 1. The cocaine esterase mutant is characterized by the mutations T172R/G173Q/L196C/I301C, with the possibility of additional mutations such as V116K or A51 site mutations, where the A51 site mutation can be L, Y, V, F, or W. The catalytic efficiency of this mutant, when screened on the cocaine toxic metabolite benzoylecgonine, shows significant improvement compared to the wildtype enzyme.

Career Highlights

Junsen Tong is affiliated with Hangzhou Normal University, where he conducts his research and development activities. His work has garnered attention for its potential applications in reducing cocaine toxicity, showcasing his innovative approach to enzyme modification.

Collaborations

Junsen Tong collaborates with esteemed colleagues, including Xiabin Chen and Jianzhuang Yao. Their combined expertise contributes to the advancement of research in biochemistry and enzyme technology.

Conclusion

Junsen Tong's innovative work on cocaine esterase mutants represents a significant advancement in the field of biochemistry. His contributions have the potential to lead to important applications in medical science, particularly in addressing cocaine toxicity.