Juergen Wolfrum

Title: Juergen Wolfrum: Innovator in Optical Characterization and Laser Applications

Introduction

Juergen Wolfrum is a notable inventor based in Rosdorf, Germany. He has made significant contributions to the fields of optical characterization and laser applications, holding a total of 2 patents. His innovative work has implications in the areas of DNA sequencing and biological material manipulation.

Latest Patents

Wolfrum's latest patents include a method for the enzymatic sequencing of DNA, which utilizes dideoxythio-nucleotides or dideoxyamino-nucleotides as terminators. These terminators are labeled with one or two fluorescent dyes, which can be coupled either before or after polymerization. The resulting dye-labeled DNA fragments are then separated in a single lane of a separation system, allowing for the identification of the terminal bases by measuring the fluorescent lifetime of the attached dyes. Another significant patent involves a method for applying cuts, perforations, and microlesions to biological materials using laser pulses. This method focuses the laser pulses to a diffraction-limited cross-section, utilizing the nth order diffraction maxima to apply precise cuts to cell agglomerates, individual cells, or chromosomes.

Career Highlights

Throughout his career, Juergen Wolfrum has demonstrated a commitment to advancing scientific knowledge and technology. His innovative approaches have garnered attention in the scientific community, particularly in the fields of genetics and laser technology.

Collaborations

Wolfrum has collaborated with esteemed colleagues such as Karl Otto Gruelich and Claus Seidel, contributing to a rich exchange of ideas and advancements in their respective fields.

Conclusion

Juergen Wolfrum's contributions to optical characterization and laser applications highlight his role as a significant inventor in modern science. His patents reflect a dedication to innovation that continues to influence research and technology today.