Company Filing History:
Years Active: 2020-2025
Title: Innovations by Joshua Spechler in Tissue Engineering
Introduction
Joshua Spechler is an accomplished inventor based in Cherry Hill, NJ (US). He has made significant contributions to the field of tissue engineering, holding 2 patents that focus on advanced methods for cell alignment and growth.
Latest Patents
His latest patents include a three-dimensional (3D) tissue scaffold with cell alignment. This innovation involves polymeric substrates, treated with a thin layer of photoresist, which are perforated by laser ablation. After the removal of the photoresist, the polymer substrates are patterned in stripes through photolithography. This process is followed by the synthesis of a cell-adhesive organometallic/self-assembled monolayer of phosphonate (SAMP) interface in the exposed regions. This provides well-aligned continuous stripes for various levels of perforation. Cells plated on these two-dimensional (2D) perforated surfaces attach to the interface and spread in alignment with high pattern fidelity, similar to that measured on a non-perforated, patterned substrate. A stack of such 2D patterned polymers yields a 3D device that facilitates cell growth and viability via the perforations. Another notable patent focuses on the patterning of fragile or non-planar surfaces for cell alignment. This construct supports cell attachment and alignment, including a substrate that is incompatible with photolithography conditions. It contains a physical pattern on at least part of one surface, which may bear a coating of a metal alkoxide, oxide, or mixed oxide-alkoxide. A Self-Assembled Monolayer of Phosphonate (SAMP) is covalently attached, containing functionality adapted for cell binding. The construct may also include cells attached to it, along with methods for preparing such a construct.
Career Highlights
Joshua Spechler is currently affiliated with Princeton University, where he continues to advance research in tissue engineering and related fields. His work has garnered attention for its innovative approaches to enhancing cell growth and alignment.
Collaborations
He collaborates with notable colleagues, including Jeffrey J Schwartz and Romain Fardel, contributing to a dynamic research environment that fosters innovation.
Conclusion
Joshua Spechler's contributions to tissue engineering through his patents and research at Princeton University highlight his role as a leading inventor in the field. His work continues