Joseph G Brewen

Title: Joseph G Brewen: Innovator in Diagnostic Reagents

Introduction

Joseph G Brewen is a notable inventor based in Convent Station, NJ (US). He has made significant contributions to the field of diagnostic reagents, holding a total of 2 patents. His work focuses on innovative methods for detecting target nucleotide sequences in biological samples.

Latest Patents

Joseph G Brewen's latest patents include the "Displacement polynucleotide assay method" and "polynucleotide complex." The first patent discloses a diagnostic reagent that contains a complex of a probe polynucleotide (P) bound via purine/pyrimidine hydrogen bonding to a labeled polynucleotide (L). The probe (P) features a target binding region (TBR) that can bind to a target nucleotide sequence (G) found in a biological sample. The method involves contact with a sample containing the target nucleotide sequence (G), leading to initial binding between G and a single-stranded portion (IBR) of the TBR. Subsequently, the labeled polynucleotide (L) is displaced from the complex through branch migration of (G) into the (P)/(L) binding region. The determination of the displaced labeled polynucleotide (L) provides a value that reflects the presence and concentration of the target nucleotide sequence (G) in the sample.

The second patent, "Displacement polynucleotide assay employing polyether and diagnostic kit," also describes a similar diagnostic reagent. It emphasizes the use of a volume-excluding polymeric agent, such as poly(ethylene oxide) (PEO or PEG) or other polyethers, to enhance the rate of appearance of the displaced labeled polynucleotide. This method also allows for the determination of the displaced labeled polynucleotide (L) to assess the presence and concentration of the target nucleotide sequence (G) in the sample.

Career Highlights

Throughout his career, Joseph G Brewen has worked with prominent companies, including Allied Corporation and Genetics Institute, Inc. His experience in these organizations has contributed to his expertise in the field of biotechnology and diagnostics.

Collaborations

Joseph has collaborated with notable individuals in his field, including Steven E Diamond and Jon I Williams. These collaborations have likely enriched his work and contributed to the development of his innovative patents.

Conclusion

Joseph G Brewen is a distinguished inventor whose