Company Filing History:
Years Active: 1996-1998
Title: Innovations of Jone L Ko in Hematopoietic Research
Introduction: Jone L Ko is a notable inventor based in Sudbury, Massachusetts, recognized for his contributions in the field of biochemistry, particularly concerning hematopoietic cells. With two patents to his name, Ko's work continues to influence scientific research and applications.
Latest Patents: One of Jone L Ko's significant patents is the "D4 gene and methods of use thereof." This invention details the molecular structure and expression of a cDNA clone, known as D4, that is preferentially expressed in hematopoietic cells. The human cDNA clone has been successfully expressed in bacteria, leading to the purification of a predicted 24 Kd protein. This protein has been employed in biochemical studies, showcasing its capability as a GDP-dissociation inhibitor for various small GTP-binding proteins, including CDC42 and Rac. The resulting D4 protein has formed the basis for a polyclonal antibody development, further advancing research into gene-targeting vectors that can create animal models deficient in D4 for both fundamental and applied research into GTP-binding proteins.
Career Highlights: Jone L Ko is affiliated with The Beth Israel Hospital Association, where he has been instrumental in advancing research and innovation in molecular biology. His work underscores the intersection of genetics, protein function, and their implications in health and disease.
Collaborations: Throughout his career, Ko has collaborated with esteemed colleagues such as Bing Lim and Jean-Michel Lelias. Together, they have contributed to the enhancement of knowledge and applications concerning hematopoietic biology, leveraging their collective expertise to push the boundaries of current research.
Conclusion: Jone L Ko's innovative work, especially through his patent related to the D4 gene, represents a significant advancement in the study of hematopoietic cells and their functions. As research continues to evolve, his contributions will undoubtedly serve as a foundational resource for future scientific inquiry.