Years Active: 2025
Title: Innovations in Cancer Diagnosis and Treatment by Johnny C Loke
Introduction
Johnny C Loke is an accomplished inventor based in Valley Cottage, NY (US). He has made significant contributions to the field of cancer research, particularly in diagnosing and treating germline mismatch repair deficiencies, commonly associated with Lynch Syndrome. His innovative work aims to enhance the understanding and management of hereditary cancer risks.
Latest Patents
Johnny C Loke holds a patent for "Methods and compositions for diagnosing and treating germline mismatch repair deficiencies, Lynch syndrome and assessing germline risks of cancer." This patent addresses the critical role of heritable pathogenic variants in the mismatch repair (MMR) pathway, which can lead to the development of colon cancer and other malignancies. The patent outlines the development of flow cytometry-based functional variant assays (FVAs) that determine whether variants in MMR repair genes augment the nuclear translocation of key proteins in response to DNA mismatches. The assays effectively distinguish pathogenic variants from benign controls, providing a robust method for identifying Lynch Syndrome and associated cancer risks.
Career Highlights
Throughout his career, Johnny C Loke has focused on advancing cancer diagnostics and treatment methodologies. His innovative approaches have the potential to significantly impact patient care by providing more accurate assessments of cancer risks associated with genetic variants. His work exemplifies the intersection of research and practical application in the medical field.
Collaborations
Johnny C Loke has collaborated with notable colleagues, including Harry Ostrer and Ishraq Alim. These partnerships have contributed to the development and validation of his innovative assays, enhancing the overall impact of his research.
Conclusion
Johnny C Loke's contributions to cancer research through his patented methods and compositions represent a significant advancement in the field. His work not only aids in the diagnosis and treatment of Lynch Syndrome but also enhances the understanding of hereditary cancer risks. The potential applications of his research could lead to improved patient outcomes and a deeper understanding of cancer genetics.