Company Filing History:
Years Active: 1999
Title: John Stephen Miles: Innovator in Genetic Assays
Introduction
John Stephen Miles is a notable inventor based in West Bridgford, GB. He has made significant contributions to the field of genetics, particularly through his innovative patent related to genetic assays. His work has implications for understanding drug metabolism in individuals.
Latest Patents
John Stephen Miles holds a patent for a genetic assay that identifies polymorphisms at specific positions of the cytochrome P450 enzyme bufuralol-1'-hydroxylase. This patent indicates that these polymorphisms are indicative of extensive metaboliser or poor metaboliser phenotypes. The detection of these phenotypes can be achieved using established methods such as DNA amplification through polymerase chain reaction, followed by digestion with a suitable restriction enzyme and analysis via gel electrophoresis. The identification of the EM/PM phenotype is crucial for calculating safe or effective drug doses for individuals.
Career Highlights
John Stephen Miles is associated with Imperial Cancer Research Technology, Ltd., where he applies his expertise in genetic research. His work has contributed to advancements in personalized medicine, particularly in the context of pharmacogenomics.
Collaborations
He has collaborated with notable colleagues, including Charles Roland Wolf and Nigel Kay Spurr, to further enhance the impact of his research in the field of genetics.
Conclusion
John Stephen Miles is a distinguished inventor whose work in genetic assays has the potential to transform the way drug doses are calculated for individuals based on their genetic makeup. His contributions to the field are invaluable and continue to influence research and development in pharmacogenomics.