Company Filing History:
Years Active: 1986-1987
Title: The Innovations of John H. Wilton
Introduction
John H. Wilton is a notable inventor based in Ann Arbor, MI (US), recognized for his contributions to the field of antimicrobial and antitumor compounds. With a total of three patents to his name, Wilton has made significant strides in the development of novel compounds that exhibit potent biological activities.
Latest Patents
One of Wilton's latest patents is for the CL-1577-B.sub.4 compound, which is produced through the solvolysis of either the CL-1577A or CL-1577B compounds. These compounds are derived from the fermentative action of a purified strain of Actinomycete designated ATCC 39363 under aerobic conditions. The CL-1577-B.sub.4 compound is recognized as a potent antimicrobial agent, effective against various gram-positive and gram-negative bacteria, yeasts, and fungi. Additionally, it demonstrates in vivo activity against the P388 murine leukemia cell line and in vitro activity against the L1210 murine leukemia cell line. The patent also discloses methods for producing the compound, as well as pharmaceutical compositions and their applications.
Another significant patent involves antimicrobial and antitumor phenazine carboxaldehydes and derivatives. This patent details acids, esters, imine acids, imine esters, and imine amides derived from 6-formyl-4,7,9-trihydroxy-1-phenazinecarboxylic acid and its methyl ester. These compounds exhibit both antimicrobial and antineoplastic activity. A purified strain of Streptomyces galanosa, NRRL 15738, is capable of producing the 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid in isolable quantities from a fermentation broth containing suitable carbon and nitrogen sources.
Career Highlights
Wilton is currently associated with Warner-Lambert Company, where he continues to innovate and develop new compounds. His work has significantly impacted the pharmaceutical industry, particularly in the areas of antimicrobial and antitumor research.
Collaborations
Throughout his career, Wilton has collaborated with notable colleagues, including Gerard C. Hokanson and James C. French. These collaborations have further enhanced the research and development of his patented compounds.
Conclusion
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