John H Lawrence, Iii

Title: Innovations by John H. Lawrence, III

Introduction

John H. Lawrence, III is a notable inventor based in Reisterstown, MD (US). He has made significant contributions to the field of gene delivery, holding a total of 3 patents. His work focuses on developing methods and compositions that enhance the delivery of nucleic acids to targeted cells, particularly in solid organs like the heart.

Latest Patents

One of his latest patents involves gene delivery compositions and methods that enable effective delivery of nucleic acids to desired cells. This innovation allows for efficient gene transfer and expression in a majority of cells throughout solid organs, such as the mammalian heart. The methods developed provide enhanced vascular permeability, which facilitates increased gene transfer to targeted cells without causing significant degradation or injury to endothelial cell layers. Remarkably, global delivery of nucleic acid to an intact heart has been achieved with as little as 2 minutes of intracoronary exposure to the administered nucleic acid.

Career Highlights

John H. Lawrence, III is affiliated with Johns Hopkins University, where he continues to advance research in gene delivery technologies. His work has the potential to revolutionize treatments for various cardiovascular conditions by improving the efficiency of gene therapy.

Collaborations

He collaborates with J. Kevin Donahue, contributing to the development of innovative solutions in the field of gene therapy.

Conclusion

John H. Lawrence, III's contributions to gene delivery methods represent a significant advancement in medical technology. His innovative approaches have the potential to enhance therapeutic outcomes for patients with heart conditions.