Johannes Brussee

Title: Innovations of Johannes Brussee

Introduction

Johannes Brussee is a notable inventor based in Rijnsburg, Netherlands. He has made significant contributions to the field of pharmaceutical sciences, particularly in the modulation of adenosine receptors. With a total of four patents to his name, Brussee's work has the potential to impact therapeutic methods significantly.

Latest Patents

Brussee's latest patents focus on A3 adenosine receptor allosteric modulators. The claimed subject matter relates to allosteric modulation of the A3 adenosine receptor (AAR) and provides for the use of an A3 adenosine receptor modulator (ARM) for the preparation of pharmaceutical compositions. These compositions are designed to modulate the AAR in a subject, including therapeutic methods that involve administering an effective amount of an ARM to modulate AAR activity. The ARM according to the claimed subject matter includes 1H-Imidazo-[4,5-c]quinolin-4-amine derivatives, which are also provided in the patent.

Career Highlights

Throughout his career, Brussee has worked with prestigious institutions such as Leiden University and the National Institutes of Health, a component of the US Department of Health & Human Services. His work in these organizations has allowed him to advance his research and contribute to the scientific community.

Collaborations

Brussee has collaborated with notable colleagues, including Adriaan Pieter Ijzerman and Zhan-Guo Gao. These collaborations have likely enriched his research and led to innovative developments in his field.

Conclusion

Johannes Brussee's contributions to the field of pharmaceutical sciences through his patents on A3 adenosine receptor modulators highlight his innovative spirit and dedication to advancing medical research. His work continues to pave the way for new therapeutic approaches.