Company Filing History:
Years Active: 2007
Title: Jiri Kalabis: Innovator in Organotypic Intestinal Culture
Introduction
Jiri Kalabis is a notable inventor based in Cambridge, MA (US). He has made significant contributions to the field of biomedical research, particularly in the development of organotypic cultures. His work focuses on creating artificial environments that mimic human intestinal conditions, which can be crucial for various therapeutic applications.
Latest Patents
Kalabis holds a patent for an "Organotypic intestinal culture and methods of use thereof." This innovative patent describes an organotypic culture that consists of an artificial stroma overlaid with epithelial cells isolated from a human colon or intestine. The stroma is composed of a mixture of collagen and human fibroblasts, also sourced from the human colon or intestine. The culture incorporates factors that bind to the IGF-1 receptor, EGF receptor, and LIF receptor. These factors can be introduced exogenously through the medium or expressed by recombinantly engineered cell types within the culture. The resulting organotypic culture can replicate in situ-like growth or emphasize different physiological or morphological states, depending on the growth media's factor balance. This culture can be utilized for screening therapeutic, carcinogenic, or growth enhancement factors, as well as for treating intestinal injuries.
Career Highlights
Kalabis is affiliated with The Wistar Institute of Anatomy & Biology, where he continues to advance his research in organotypic cultures. His work has the potential to impact various fields, including drug development and regenerative medicine.
Collaborations
One of his notable collaborators is Meenhard Herlyn, with whom he has worked on various research projects aimed at enhancing the understanding of intestinal biology and its applications in medicine.
Conclusion
Jiri Kalabis is a pioneering inventor whose work in organotypic intestinal culture represents a significant advancement in biomedical research. His contributions have the potential to lead to breakthroughs in therapeutic applications and improve treatment strategies for intestinal injuries.