Location History:
- Cordova, TN (US) (2000 - 2001)
- Memphis, TN (US) (2006)
Company Filing History:
Years Active: 2000-2006
Title: The Innovative Contributions of Jill M. Lahti
Introduction
Jill M. Lahti is a prominent inventor based in Memphis, TN (US). She has made significant contributions to the field of biomedical research, particularly in the area of tumor suppressor proteins and their implications in cancer diagnostics and therapeutics. With a total of 3 patents to her name, her work has the potential to impact the future of cancer treatment.
Latest Patents
One of her latest patents focuses on a tumor suppressor protein involved in death signaling, diagnostics, therapeutics, and screening based on this protein. This invention relates to the identification of tumor suppressor activity of the protein caspase-8 (CASP8). The discovery highlights the tumor suppressor activity of CASP8, which is functionally inactivated in over 90% of MYCN amplified neuroblastoma cell lines. The patent describes methods for screening compounds that can overcome gene inactivation resulting from genomic methylation of the promoter.
Another significant patent by Lahti involves cyclin-C variants and their diagnostic and therapeutic uses. This invention includes alternatively and partially spliced cyclin C mRNAs and the truncated protein they encode. The research demonstrates that at least one of the alternatively spliced cyclin C mRNAs is produced in a cell cycle-dependent manner. The truncated cyclin C acts as an inhibitor by negatively regulating cyclin C/cdk8 complex activity, similar to other cyclin-dependent protein kinase inhibitors.
Career Highlights
Jill M. Lahti is affiliated with St. Jude Children's Research Hospital, where she conducts her research. Her work is instrumental in advancing the understanding of cancer biology and developing new therapeutic strategies.
Collaborations
Lahti has collaborated with notable colleagues, including Vincent J. Kidd and Tal Teitz, contributing to a rich environment of innovation and research excellence.
Conclusion
Jill M. Lahti's innovative work in the field of cancer research exemplifies the impact of dedicated inventors on medical science. Her patents not only advance our understanding of tumor suppressor proteins but also pave the way for future therapeutic developments.