Company Filing History:
Years Active: 2000
Title: Innovator Spotlight: Jia Le Dai and His Contributions to Molecular Biology
Introduction: Jia Le Dai, based in Owings Mills, MD, has made significant strides in the field of molecular biology, particularly through his patented inventions. His research work has helped illuminate the roles of specific proteins in gene regulation, paving the way for advancements in medical diagnostics and therapeutics.
Latest Patents: Jia Le Dai holds a patent for his innovative discovery titled "Human Smad3 and Smad4 are sequence-specific transcription activators." This patent details how the two human Smad proteins, Smad3 and Smad4, specifically recognize an identical 8 bp palindromic sequence (GTCTAGAC). The research demonstrates that tandem repeats of this palindrome significantly enhance TGF-β responsiveness to a minimal promoter, a response that is lost when the Smad4 gene is deleted. Furthermore, DNA molecules containing this 8 bp sequence can be instrumental in drug screening assays and diagnostic applications.
Career Highlights: Jia Le Dai is affiliated with The Johns Hopkins University, a prestigious institution renowned for its innovative research and contributions to science and medicine. His work has been instrumental in understanding transcriptional regulatory mechanisms in human cells, particularly the roles of Smad proteins in the transforming growth factor-beta (TGF-β) signaling pathway.
Collaborations: Throughout his career, Jia has collaborated with esteemed colleagues, including Scott E Kern and Leigh Zawel. These partnerships reflect a commitment to advancing scientific knowledge and fostering innovation within the field of molecular biology.
Conclusion: Jia Le Dai's contributions to science, exemplified by his patent, highlight the importance of research in understanding gene regulation and its implications for drug development and diagnostics. As he continues his work at The Johns Hopkins University, his research may lead to groundbreaking advancements that can ultimately enhance therapeutic approaches in medicine.