Company Filing History:
Years Active: 1995-2002
Title: Innovations by Jessica A Gorman
Introduction
Jessica A Gorman is a notable inventor based in Yardley, PA (US). She has made significant contributions to the field of biotechnology, particularly in the development of innovative receptor/kinase chimeras. With a total of 4 patents, her work has implications for understanding and treating various diseases.
Latest Patents
One of her latest patents is titled "Functional receptor/kinase chimera in yeast cells." This invention involves a functional mammalian growth factor receptor fused with the intracellular kinase domain of the SLN1 gene. The SLN1 gene encodes the plasma membrane sensor kinase of the yeast high osmolarity/glycerol response MAP kinase pathway. The chimeric protein is almost completely nonfunctional without a ligand, but in its presence, the chimeric kinase is activated, allowing for the quantitative repression of pathway phosphorylation. This measure of pathway activity can be utilized to identify agonists and antagonists of the EGFR and other tyrosine kinase growth factor receptors in yeast cells. Another significant patent is related to a recombinant yeast cell that expresses the kinase domain of N-Pak, which restores the mating function of a ste20 mutant. This invention is particularly useful for screening inhibitors of N-Pak, which may have applications in the treatment and prevention of Alzheimer's Disease.
Career Highlights
Throughout her career, Jessica has worked with prominent companies such as Bristol-Myers Squibb Company and E.R. Squibb & Sons, Inc. Her experience in these organizations has contributed to her expertise in the field of biotechnology and patent development.
Collaborations
Jessica has collaborated with several professionals in her field, including Catherine A Bingham and Darin B Ostrander. These collaborations have likely enriched her research and innovation efforts.
Conclusion
Jessica A Gorman's contributions to biotechnology through her patents and collaborations highlight her role as an influential inventor. Her work continues to pave the way for advancements in medical research and treatment options.