Company Filing History:
Years Active: 2020-2022
Title: Jerome Escano: Innovator in Modified Lantibiotics
Introduction
Jerome Escano is a notable inventor based in College Station, TX (US). He has made significant contributions to the field of biochemistry, particularly in the development of modified lantibiotics. With a total of 2 patents, his work is paving the way for advancements in antibacterial treatments.
Latest Patents
Escano's latest patents focus on modified lantibiotics and methods of making and using these innovative compounds. The subject invention pertains to a modified lantibiotic containing an intact cysteine at the C-terminus, specifically a cysteine that is not decarboxylated and retains a free carboxyl group. His patents also describe derivatives of the modified lantibiotic that include a moiety conjugated to the carboxyl group of the terminal cysteine. Furthermore, he has developed a genetically modified bacterium that produces a modified lantibiotic with an intact cysteine at the C-terminus. This bacterium is engineered to inactivate a gene encoding a decarboxylase enzyme that decarboxylates the cysteine at the C-terminus of a precursor lantibiotic. The methods outlined in his patents include culturing a bacterium that synthesizes the modified lantibiotic and purifying the lantibiotic. Additionally, mutants of lantibiotics, particularly mutacin 1140, are provided, which exhibit higher antibacterial activity or enhanced bacterial expression compared to the original mutacin 1140.
Career Highlights
Jerome Escano is affiliated with the Texas A&M University System, where he continues to engage in research and innovation. His work has garnered attention for its potential applications in medical and pharmaceutical fields.
Collaborations
One of his notable coworkers is James Leif Smith, with whom he collaborates on various research projects.
Conclusion
Jerome Escano's contributions to the field of modified lantibiotics represent a significant advancement in antibacterial research. His innovative patents and ongoing work at the Texas A&M University System highlight his commitment to improving health outcomes through scientific discovery.