Company Filing History:
3 out of 49 
1 out of 832,812 Years Active: 2000-2010
Title: Innovations by Jeffrey Roberts Lee
Introduction
Jeffrey Roberts Lee is an accomplished inventor based in Martinez, GA (US). He holds a total of four patents, showcasing his contributions to the field of medical research and diagnostics. His work primarily focuses on assessing the risk of tumor progression and developing innovative screening methods for gastric cancer.
Latest Patents
One of his latest patents involves the development of kits to assess the risk of tumor progression. This invention is based on the discovery that antigen-presenting cells (APCs) can be engineered to express predetermined levels of the intracellular enzyme, indoleamine 2,3-dioxygenase (IDO). High levels of IDO are associated with a reduced ability to stimulate T cell responses, which can enhance immunologic tolerance. These APCs can be utilized in transplant therapy or the treatment of autoimmune disorders. The kits include reagents for detecting IDO in tissue samples from tumors or tumor-draining lymph nodes, packaged in individual containers.
Another significant patent focuses on screening for gastric adenocarcinoma. Lee identified a specific metaplastic lineage that expresses a trefoil polypeptide, spasmolytic peptide, which is linked to the majority of human adenocarcinomas. This discovery is crucial for grading biopsies of the stomach to assess cancer risk. The method involves using antibodies to spasmolytic peptide in immunostaining biopsies obtained through endoscopy. Patients exhibiting these cells are at an increased risk of developing adenocarcinoma, and the tests can predict the likelihood of this progression.
Career Highlights
Throughout his career, Jeffrey Roberts Lee has made significant strides in medical research, particularly in the areas of cancer diagnostics and immunology. His innovative approaches have the potential to improve patient outcomes and enhance the understanding of tumor biology.
Collaborations
Lee has collaborated with notable professionals in his field, including James R. Goldenring and P. Henry Schmidt. These partnerships have contributed to the advancement of his research and the development of his patented technologies.
Conclusion
Jeffrey Roberts Lee's contributions to medical research through his patents reflect his dedication to improving cancer diagnostics and treatment. His innovative work continues to pave the way for advancements in the understanding and management of tumor progression.