Company Filing History:
Years Active: 1998-2004
Title: Innovations of Jeffrey L. Keene
Introduction
Jeffrey L. Keene is a notable inventor based in St. Louis, MO (US). He has made significant contributions to the field of biochemistry, particularly in the development of hormone analogs. With a total of three patents to his name, his work has implications for medical science and therapeutic applications.
Latest Patents
One of his latest patents is focused on follicle stimulating hormone-glycosylation analogs. This invention provides recombinant native and mutein forms of the human follicle stimulating hormone beta subunit (FSH beta) with characteristic glycosylation patterns that influence the metabolic activity of the protein. Additionally, the invention includes recombinant mutant forms of the human alpha subunit common to FSH, LH, CG, and TSH, which yield hormones with unique glycosylation patterns. The patent also offers recombinant materials to produce these subunits separately or together, facilitating the creation of complete heterodimeric hormones with regulated glycosylation patterns. Another patent related to follicle stimulating hormone-glycosylation analogs provides recombinant materials for the production of the alpha-glycoprotein hormone subunit. These muteins serve as antagonists and can alter the pharmacokinetic activity of these hormones.
Career Highlights
Jeffrey L. Keene is affiliated with Washington University, where he continues to advance his research and innovations. His work has garnered attention for its potential applications in hormone therapy and reproductive medicine.
Collaborations
Throughout his career, Jeffrey has collaborated with esteemed colleagues such as Irving Boime and Martin Matthew Matzuk. These partnerships have contributed to the depth and impact of his research.
Conclusion
Jeffrey L. Keene's contributions to the field of biochemistry through his innovative patents highlight his role as a significant inventor. His work on hormone analogs not only advances scientific understanding but also holds promise for future medical applications.