Company Filing History:
Years Active: 1992-1996
Title: The Innovative Contributions of Jeffrey D. Parvin
Introduction
Jeffrey D. Parvin, an accomplished inventor based in Belmont, MA, has made significant contributions to the field of virology and molecular biology. With a total of two patents to his name, his work focuses on the development of innovative methods for expressing heterologous gene products through recombinant negative strand RNA viruses.
Latest Patents
Parvin's most recent patents center around recombinant negative strand RNA virus technologies. These patents describe templates that can be utilized to express heterologous gene products and construct chimeric viruses. His research employs influenza viral polymerase that has been prepared to be depleted of viral RNA. This polymerase is capable of copying small RNA templates that originate from plasmid-encoded sequences. The constructions that only contain the 3' end of genomic RNA demonstrate efficient copying, indicating that the promoter is located entirely within the 15 nucleotide 3' terminus. Notably, sequences that do not correspond to the influenza viral termini were not copied, and it was found that RNA strands with termini identical to those from plus sense cRNA were copied at lower levels. The specificity for recognizing the virus-sense promoter was refined through site-specific mutagenesis. Furthermore, it was discovered that elevated levels of viral protein are necessary to catalyze both cap-endonuclease primed and primer-free RNA synthesis from model templates and genomic-length RNAs. This discovery suggests that the reconstituted system possesses catalytic properties similar to those of native viral RNPs. High levels of expression of a heterologous gene were achieved using the described constructs and methods.
Career Highlights
Throughout his career, Jeffrey D. Parvin has worked with notable institutions such as Mount Sinai School of Medicine and Aviron. These experiences have bolstered his efforts in virology research and innovation.
Collaborations
Parvin has collaborated with esteemed scientists, including Peter M. Palese and Mark Krystal. Their combined expertise has contributed to the advancement of research and innovation in the realm of recombinant viruses.
Conclusion
Jeffrey D. Parvin exemplifies the spirit of innovation with his contributions to the study of recombinant negative strand RNA viruses. His patents and collaborative efforts underscore his influential role in advancing virology, paving the way for future discoveries and applications in genetic research.