Location History:
- Berkeley, CA (US) (2014)
- Irvine, CA (US) (2016)
- Urbana, IL (US) (2020)
Company Filing History:
3 out of 15,528 
1 out of 4,555 
Years Active: 2014-2020
Title: Jefferson Y Chan: Innovator in Formaldehyde Detection and Apoptosis Enhancement
Introduction
Jefferson Y Chan is a notable inventor based in Irvine, CA, who has made significant contributions to the fields of chemical detection and cellular biology. With a total of 3 patents, his work focuses on innovative methods and compositions that enhance the detection of formaldehyde and improve apoptosis in mammalian cells.
Latest Patents
One of Chan's latest patents involves the development of homoallylamines as formaldehyde-responsive triggers. This patent provides probes for formaldehyde, which include a homoallylamine trigger group attached to a detectable moiety. The probes are designed to be luminogenic or fluorogenic, featuring a quencher in energy-receiving proximity to a fluorophore. The methods outlined in this patent allow for sensitive and bioorthogonal detection of formaldehyde in various samples, including cells, tissues, organs, or fluids in subjects. Another significant patent focuses on methods for preventing induced synthesis of proteasomes in human cells. This invention provides methods and compositions for inhibiting Nrf1 activity, which enhances apoptosis in mammalian cells by co-inhibiting Nrf1 and proteasome activity.
Career Highlights
Throughout his career, Chan has worked with prestigious institutions such as the University of California and the California Institute of Technology. His research has led to advancements in understanding and manipulating cellular processes, particularly in the context of apoptosis and chemical detection.
Collaborations
Chan has collaborated with notable colleagues, including Christopher J Chang and Genevieve C Van De Bittner, contributing to a rich exchange of ideas and innovations in his field.
Conclusion
Jefferson Y Chan's innovative work in formaldehyde detection and apoptosis enhancement showcases his commitment to advancing scientific knowledge and technology. His contributions are significant in both chemical and biological research, reflecting the impact of his inventions on the scientific community.