Jean Louis Imbach

Title: Innovations of Jean Louis Imbach

Introduction

Jean Louis Imbach is a notable inventor based in Montpellier, France. He has made significant contributions to the field of biotechnology, particularly in the development of oligonucleotides. With a total of 2 patents, his work has implications for medical research and treatment.

Latest Patents

Among his latest patents is the development of oligonucleotides having a conserved G4 core sequence. This innovation includes inhibitors of the human immunodeficiency virus (HIV). The phosphorothioate oligonucleotide T.sub.2 G4T2 was identified as an inhibitor of HIV infection in vitro through combinatorial screening of a library of phosphorothioate oligonucleotides that contained all possible 8-nucleotide sequences. The oligonucleotide forms a parallel-stranded tetrameric guanosine-quartet (G-quartet) structure. Tetramer formation and the phosphorothioate backbone are essential for antiviral activity. The G-quartet structure binds to the HIV envelope protein gp120 at the V3 loop and inhibits both cell-to-cell and virus-to-cell infection.

Career Highlights

Jean Louis Imbach has worked at Isis Pharmaceuticals, Inc., where he has been involved in groundbreaking research. His work has contributed to advancements in therapeutic strategies against viral infections.

Collaborations

He has collaborated with notable coworkers such as David J Ecker and Jacqueline R Wyatt, enhancing the impact of his research through teamwork and shared expertise.

Conclusion

Jean Louis Imbach's contributions to the field of biotechnology, particularly in the development of antiviral oligonucleotides, highlight his innovative spirit and dedication to improving medical treatments. His work continues to influence research in combating viral infections.