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Years Active: 2024
Title: Jean Darcourt: Innovator in Vascular Health
Introduction
Jean Darcourt is a notable inventor based in Toulouse, France. He has made significant contributions to the field of vascular health, particularly in understanding and addressing ischemic conditions. His work focuses on preserving vascular endothelial cell barrier integrity, which is crucial for patient recovery following ischemic events.
Latest Patents
Darcourt holds a patent for the "Use of PI3KC2B inhibitors for the preservation of vascular endothelial cell barrier integrity." This invention addresses the critical issue of ischemia, a condition characterized by reduced blood flow and oxygen to an organ. The patent highlights the importance of re-establishing blood flow and re-oxygenation after an ischemic episode to limit irreversible damage. However, it also acknowledges the potential damaging consequences of reperfusion, such as increased vascular permeability, which contributes to edema and tissue damage. His research demonstrates that genetic inhibition of PI3K-C2β reduces cerebral infarction in two ischemia/reperfusion models and improves neurological outcomes. This genetic inhibition stabilizes the blood-brain barrier after ischemic stroke and reduces inflammation. The invention provides a method for preserving vascular endothelial cell barrier integrity in patients by administering a therapeutically effective amount of a PI3KC2β inhibitor.
Career Highlights
Throughout his career, Jean Darcourt has worked with esteemed institutions, including the Institut National de la Santé et de la Recherche Médicale and Université Paul Sabatier Toulouse III. His research has significantly advanced the understanding of vascular health and the mechanisms involved in ischemic conditions.
Collaborations
Darcourt has collaborated with notable colleagues, including Marie-Pierre Gratacap and Bart Vanhaesebroeck. Their combined expertise has contributed to the success of his research and innovations in the field.
Conclusion
Jean Darcourt's work in vascular health and his innovative patent for PI3KC2B inhibitors represent significant advancements in the treatment of ischemic conditions. His contributions continue to impact the medical field positively.