Jason D Weber

Title: Jason D Weber: Innovator in Cell Cycle Regulation

Introduction

Jason D Weber is a notable inventor based in Memphis, TN (US). He has made significant contributions to the field of cell biology, particularly in understanding the mechanisms that regulate the mammalian cell cycle. His work has implications for cancer research and treatment.

Latest Patents

One of Jason D Weber's key patents is ARF-P19, a novel regulator of the mammalian cell cycle. The INK4A (MTS1, CDKN2) gene encodes a specific inhibitor, InK4a-p16, which plays a crucial role in blocking cyclin D-dependent kinases CDK4 and CDK6. This inhibition prevents the phosphorylation of the retinoblastoma protein (pRb), thereby blocking the exit from the G1 phase of the cell cycle. The significance of this patent lies in its potential to suppress tumor formation, as deletions and mutations in the INK4A gene are frequently observed in cancer cells. Additionally, ARF-p19, which arises from an alternative reading frame of the mouse INK4A gene, has been shown to induce both G1 and G2 phase arrest in rodent fibroblasts. This economical reutilization of protein coding sequences is unprecedented in mammalian genomes.

Career Highlights

Jason D Weber is affiliated with St. Jude Children's Research Hospital, where he continues to advance research in cell cycle regulation. His work is critical in understanding the dual requirements for both InK4a-p16 and ARF-p19 in cell cycle control.

Collaborations

Throughout his career, Jason has collaborated with esteemed colleagues such as Charles J Sherr and Dawn E Quelle. These collaborations have further enriched his research and contributed to advancements in the field.

Conclusion

Jason D Weber's innovative work in cell cycle regulation exemplifies the importance of research in understanding cancer biology. His contributions through patents and collaborations continue to pave the way for future discoveries in this vital area of science.