Jane-Jane Chen

Title: The Innovative Contributions of Jane-Jane Chen

Introduction

Jane-Jane Chen is a prominent inventor based in Belmont, MA (US). He has made significant contributions to the field of molecular biology, particularly in the area of protein synthesis regulation. With a total of 2 patents, his work has implications for cancer research and treatment.

Latest Patents

One of his latest patents involves the DNA encoding the heme-regulated eukaryotic initiation factor 2.alpha. This patent details the cloning of cDNA that encodes heme-regulated eIF-2.alpha. kinase (HRI) from a lambda Zap II cDNA library of rabbit reticulocytes. The rabbit HRI cDNA shows a high degree of homology to human HRI and hybridizes to human HRI DNA under moderately stringent conditions. The cDNA contains 2729 amino acids, and in vitro translation of HRI mRNA yields a 90 kDa polypeptide with eIF-2.alpha. kinase activity. HRI acts as a potent inhibitor of protein synthesis, making it anti-proliferative in nature. The high homology of HRI to three protein kinases involved in cell division regulation suggests its direct role in this process. The cDNA can be inserted into cells to manipulate proliferation and differentiation, particularly in cancer cells. Additionally, deletion mutants of HRI cDNA can be constructed to enhance its anti-viral and anti-proliferative actions.

Career Highlights

Jane-Jane Chen is affiliated with the Massachusetts Institute of Technology, where he continues to advance research in his field. His innovative work has garnered attention and respect within the scientific community.

Collaborations

He has collaborated with notable individuals, including Irving M London, to further his research endeavors.

Conclusion

Jane-Jane Chen's contributions to the field of molecular biology and his innovative patents highlight the importance of research in understanding and manipulating protein synthesis. His work has the potential to impact cancer treatment and other areas of medical research significantly.