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Title: The Innovative Contributions of Jane Buckner
Introduction
Jane Buckner is a prominent inventor based in Seattle, Washington. She has made significant contributions to the field of medical research, particularly in the area of rheumatoid arthritis. Her work focuses on the identification and medical applications of anti-citrullinated-protein antibodies, which are crucial for understanding and diagnosing this autoimmune condition.
Latest Patents
Jane Buckner holds a patent titled "Identification and medical applications of anti-citrullinated-protein antibodies in rheumatoid arthritis - Compositions and methods for detection of anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) patients." This patent involves probing patient samples known or suspected of containing ACPAs against citrullinated proteins. Her research investigated antibody responses to 190 citrullinated proteins in 20 RA patients, revealing unique antibody reactivity patterns in both clinical anti-cyclic citrullinated peptide assay positive (CCP+) and negative (CCP−) RA patients. Notably, she discovered and validated six novel antibody/antigen complexes against specific citrullinated antigens, including Myelin Basic Protein (MBP) and insulin-like growth factor I (IGF1). The identified biomarkers, particularly MBP, exhibit high specificity for RA.
Career Highlights
Throughout her career, Jane Buckner has worked with esteemed institutions such as Arizona State University and the Benaroya Research Institute at Virginia Mason. Her research has significantly advanced the understanding of rheumatoid arthritis and its underlying mechanisms.
Collaborations
Jane has collaborated with notable colleagues, including Joshua LaBaer and Ji Qiu, contributing to the advancement of research in her field.
Conclusion
Jane Buckner's innovative work in the identification of anti-citrullinated-protein antibodies has made a lasting impact on the diagnosis and understanding of rheumatoid arthritis. Her contributions continue to influence medical research and improve patient outcomes.