Company Filing History:
Years Active: 1986-1994
Title: Innovations of James P O'Connell
Introduction
James P O'Connell is a notable inventor based in Chapel Hill, NC (US). He has made significant contributions to the field of enzyme immunoassays, holding a total of 9 patents. His work focuses on developing methods that enhance the detection of ligands in liquid samples.
Latest Patents
One of his latest patents is for Fluoroketone enzyme inhibitors. This invention describes a method for enzyme immunoassay that includes signal amplification through the use of at least two enzymes and a blocked modulator for one of the enzymes. The ligand present in the liquid binds to an antiligand and an enzyme-labeled tracer. The resulting bound fraction is separated, and the enzyme in the tracer removes the blocking group from the blocked modulator. The modulator then activates or inhibits a second enzyme, which catalyzes the conversion of a substrate to a product. The presence or absence of the ligand is indicated by a signal, such as a color change or a rate of color change, associated with the product. This invention also includes a new class of enzyme inhibitors and blocked inhibitors, along with a kit of materials useful for performing the method.
Another significant patent by O'Connell is related to signal enhancement in immunoassay by modulation of enzymatic catalysis. This method also involves enzyme immunoassay for a ligand suspected to be present in a liquid sample, utilizing signal amplification through at least two hydrolases and a blocked fluoroketone for one of the hydrolases. Similar to his previous invention, the ligand binds to an antiligand and a hydrolase-labeled tracer, leading to the separation of the bound fraction. The hydrolase in the tracer removes the blocking group from the blocked fluoroketone, which then activates or inhibits a second hydrolase. The presence or absence of the ligand is indicated by a signal associated with the product. This invention introduces a new class of hydrolase inhibitors and blocked fluoroketones, along with a kit of materials for the method.
Career Highlights
James P O'Connell is currently employed at Becton Dickinson and Company Limited, where he continues to innovate in the field of enzyme immunoassays. His work has had a significant impact on the development of diagnostic methods.
Collaborations
O'Connell
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