Company Filing History:
4 out of 240 
2 out of 897 
Years Active: 1999-2021
Title: The Innovative Contributions of James E Zadina
Introduction
James E Zadina is a notable inventor based in Metairie, Louisiana. He has made significant contributions to the field of pain management through his innovative research and development of opioid receptor agonists. With a total of 4 patents to his name, Zadina's work has the potential to improve therapeutic outcomes for patients suffering from acute and chronic pain.
Latest Patents
Zadina's latest patents focus on mu opioid receptor agonist analogs of the endomorphins. The first patent describes cyclic peptide agonists that bind to the mu (morphine) opioid receptor, aimed at treating acute and chronic pain. These cyclic analogs of endomorphin demonstrate decreased tolerance compared to morphine and increased solubility relative to similar tetrapeptide analogs. Importantly, they maintain favorable or improved therapeutic ratios of analgesia to side effects. The second patent also addresses cyclic pentapeptide and hexapeptide analogs of endomorphin, featuring a carboxy-terminal extension with an amidated hydrophilic amino acid and a substitution in amino acid position 2. These advancements further enhance the potential for effective pain management.
Career Highlights
Throughout his career, Zadina has worked with esteemed organizations, including the Administrators of the Tulane Educational Fund and the United States Government as represented by the Department of Veterans Affairs. His research has been pivotal in advancing the understanding of opioid receptors and their role in pain relief.
Collaborations
Zadina has collaborated with notable colleagues such as Laszlo Hackler and Abba J Kastin. These partnerships have contributed to the depth and breadth of his research, fostering innovation in the field of pain management.
Conclusion
James E Zadina's contributions to the field of pain management through his innovative patents and collaborations highlight his commitment to improving patient care. His work continues to pave the way for advancements in therapeutic options for those in need.