James E Knobloch

Title: James E. Knobloch: Innovator in Heparin Processing

Introduction: James E. Knobloch, an inventor based in Cross Plains, WI, has made significant contributions to the field of pharmacology through his innovative processes for preparing low-affinity, low molecular weight heparins. His work holds promise for advancing medical treatments related to thrombus-related cardiovascular conditions. With one patent to his name, Knobloch is recognized for his unique approach to enhancing the therapeutic properties of heparins.

Latest Patents: James E. Knobloch holds a patent centered on "Processes for the preparation of low-affinity, low molecular weight heparins (LA-LMW-heparins)." This invention outlines a method involving the nitrous acid depolymerization of unfractionated heparin, leading to the creation of low molecular weight heparin. Subsequent processes include oxidation and reduction steps that enhance the pharmacological properties of the heparin, ultimately permitting its application in preventing thrombosis during cardiac procedures and treating thrombus-related conditions such as heart attacks and strokes.

Career Highlights: Knobloch is associated with Hamilton Civic Hospitals Research Development Inc., where his pioneering work on LA-LMW-heparins has garnered attention for its promising applications in clinical settings. His innovative methods provide an alternative solution to traditional heparin therapies, emphasizing both efficacy and safety in patient treatment.

Collaborations: Throughout his career, James E. Knobloch has worked alongside notable colleagues such as Jack Hirsh and Patrick N. Shaklee. Their collective expertise has significantly enriched research and development efforts, fostering a collaborative environment that promotes groundbreaking advancements in the medical field.

Conclusion: James E. Knobloch's work exemplifies the intersection of innovation and medical science. His patent on low-affinity, low molecular weight heparins not only showcases his inventive spirit but also his commitment to improving patient care. As research in this area continues to evolve, Knobloch's contributions are likely to play a crucial role in the ongoing fight against thrombus-related health issues.