Company Filing History:
Years Active: 2001
Title: Jacqueline F. Bromberg: Innovator in Transcription Factor Research
Introduction
Jacqueline F. Bromberg is a prominent inventor based in New York, NY (US). She has made significant contributions to the field of molecular biology, particularly in the study of transcription factors. Her innovative work has led to the development of novel methods for understanding cellular processes and their implications in disease.
Latest Patents
Jacqueline F. Bromberg holds a patent titled "Constitutively active transcription factors and their uses for identifying modulators of activity including dysproliferative cellular changes." This invention focuses on constitutively active Stat proteins and methods for their preparation. The modified Stat proteins contain at least one cysteine residue that can interact with a corresponding cysteine residue on another modified Stat protein to form a dimer. These proteins are capable of binding to DNA and activating transcription without the need for tyrosine phosphorylation. Cell lines expressing the modified Stat protein exhibit a transformed phenotype and can form tumors in nude mice. The patent also describes methods for using these modified Stat proteins to identify agents that can modulate Stat protein dimerization, transcriptional activity, and cellular transformation both in vitro and in vivo. Additionally, the invention includes polynucleotides encoding these modified, constitutively active Stat proteins.
Career Highlights
Jacqueline F. Bromberg is affiliated with The Rockefeller University, where she conducts her research. Her work has garnered attention for its potential applications in understanding and treating various diseases, particularly those related to dysregulation of cellular growth and transformation.
Collaborations
Some of her notable coworkers include Melissa H. Wrzeszczynska and Yanxiang Zhao. Their collaborative efforts contribute to advancing research in the field of transcription factors and their roles in cellular processes.
Conclusion
Jacqueline F. Bromberg's innovative research on constitutively active transcription factors has the potential to significantly impact the understanding of cellular mechanisms and disease treatment. Her contributions to molecular biology continue to inspire further research and development in this critical area.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.