J Paul Hieble

Title: J Paul Hieble: Innovator in Pharmacology

Introduction

J Paul Hieble is a notable inventor based in Philadelphia, PA, recognized for his contributions to pharmacology. He holds two patents that showcase his innovative approach to developing chemical compounds with significant biological properties.

Latest Patents

One of Hieble's latest patents is for a compound known as N,N-Di-n-propyl-4-hydroxy-3-methanesulfonamidophenethylamine. This compound acts as a potent, selective presynaptic dopaminergic agonist. The preparation of this compound involves N-sulfonylation of an optionally O-protected derivative of 3-amino-4-hydroxy-N,N-di-n-propylphenethylamine, followed by the removal of the protecting group. Another significant patent is for 2-(4-tert.-Butyl-2,6-dichlorophenylimino)imidazolidine, which is an anti-hypertensive chemical compound. This compound exhibits unexpected biological properties compared to those of clonidine.

Career Highlights

Hieble has made substantial contributions to the field of pharmacology through his work at SmithKline Beckman Corporation. His innovative research has led to the development of compounds that have the potential to impact medical treatments significantly.

Collaborations

Throughout his career, Hieble has collaborated with notable colleagues, including Robert M DeMarinis and Carl Kaiser. These collaborations have likely contributed to the advancement of his research and the successful development of his patented compounds.

Conclusion

J Paul Hieble's work in pharmacology exemplifies the impact of innovative thinking in the development of new chemical compounds. His patents reflect a commitment to advancing medical science and improving therapeutic options.