Ishraq Alim, I

Title: Innovations in Cancer Diagnosis and Treatment by Ishraq Alim, I

Introduction

Ishraq Alim, I is an accomplished inventor based in New York, NY (US). He has made significant contributions to the field of cancer research, particularly in the diagnosis and treatment of germline mismatch repair deficiencies, commonly associated with Lynch Syndrome. With a total of 4 patents, his work has the potential to impact the lives of many individuals at risk for hereditary cancers.

Latest Patents

Ishraq Alim's latest patents focus on methods and compositions for diagnosing and treating germline mismatch repair deficiencies and assessing germline risks of cancer. His research highlights the importance of understanding heritable pathogenic variants in the mismatch repair (MMR) pathway, which can lead to the development of colon cancer and other malignancies. The patents detail the role of a complex of proteins, including MLH1, MSH2, MSH6, and PMS2, which translocate into the nucleus to signal the recruitment of repair mechanisms following a mismatch.

Alim developed flow cytometry-based functional variant assays (FVAs) to determine whether variants in MMR repair genes would enhance the nuclear translocation of MLH1 and MSH2, as well as the downstream nuclear phosphorylation of ATM and ATR in response to DNA mismatches. Each assay effectively distinguished pathogenic variants in MMR repair genes from benign controls. The combination of multiple assays provided robust separation between heterozygous pathogenic variant carriers and benign controls. The ability to produce distinct molecular phenotypes through these assays suggests that FVA assays of MMR pathways could be utilized to identify Lynch Syndrome and associated risks of colon and other cancers. This innovation could serve as an adjunct to MMR gene sequencing panels in categorizing variants.

Career Highlights

Throughout his career, Ishraq Alim has worked with notable institutions, including the Burke Neurological Institute and the University of Vermont and State Agricultural College. His research has been pivotal in advancing the understanding of genetic factors in cancer development.

Collaborations

Ishraq has collaborated with esteemed colleagues such as Harry Ostrer and Rajiv R Ratan, contributing to a rich exchange of ideas and expertise in the field of cancer research.

Conclusion

Ishraq Alim, I's innovative work in the diagnosis and treatment of germline mismatch repair deficiencies showcases his commitment to