Company Filing History:
Years Active: 1986
Title: **The Innovations of Isaiah J. Fidler**
Introduction
Isaiah J. Fidler, based in Frederick, MD, is an accomplished inventor known for his significant contributions to the field of biochemistry. He holds a pivotal patent that showcases his innovative approach to utilizing iodinated lipids for scientific applications.
Latest Patents
Fidler’s notable patent involves the creation of iodinated phospholipids, specifically the compound N-(3-(3-.sup.125 iodo, 4-hydroxybenzyl)propionyl)phosphatidylethanolamine. This compound is characterized as a nonexchangeable iodinated lipid of high specific radioactivity. The patent not only details the synthesis of this compound but also introduces methods for creating various iodinated lipids by employing acylation techniques using substituted cyclic organic acids such as the monoiodinated Bolton-Hunter reagent. The innovation presented allows for the purification of these lipids through thin-layer chromatography, providing significant advancements in lipid labeling techniques.
Career Highlights
Isaiah J. Fidler's career is highlighted by his work at Litton Bionetics, Inc., where he has made substantial strides in the development of biochemical tracers. His focused research and inventive spirit have led to important advancements in the synthesis of iodinated lipids, which aid in the creation of high-sensitivity assays essential for both in vitro and in vivo studies.
Collaborations
Throughout his career, Fidler has collaborated with renowned professionals, including his colleague Alan J. Schroit. Their partnership has significantly contributed to the development of novel lipid compounds, enhancing the applicability of liposome tracers in research settings.
Conclusion
Isaiah J. Fidler stands out as an innovative inventor whose work on iodinated lipids represents significant strides in biochemical research. His contributions not only further the scientific community's understanding of lipid behavior but also enhance the methodologies available for various assays, indicating a promising future for ongoing research in this area.