Company Filing History:
Years Active: 2022-2025
Title: Irma Querques: Innovator in Gene Delivery Technologies
Introduction
Irma Querques is a prominent inventor based in Zurich, Switzerland. She has made significant contributions to the field of gene delivery technologies, holding a total of 3 patents. Her work focuses on improving transposase polypeptides, which are crucial for gene therapy applications.
Latest Patents
Irma's latest patents include a transfection method using a Sleeping Beauty transposase variant with increased solubility. This invention relates to improved transposase polypeptides that enhance gene delivery capabilities. The enzyme was developed based on the Sleeping Beauty transposase, providing further nucleic acids, vectors, and recombinant cells that encode or contain the improved transposase. This invention is particularly useful for gene delivery in genetically modified cell-based therapeutic approaches aimed at treating various diseases.
Another notable patent involves a modified Sleeping Beauty transposase polypeptide with increased solubility for transfection into cells as an isolated protein. This disclosure presents improved reagents and methods for inserting a transgene into the genome of a living host cell. The use of rational mutagenesis has led to the development of a variant SB transposase protein that is more soluble while maintaining its activity. This modified transposase is highly soluble in electroporation buffer and is thermostable during storage, promoting the integration of a transgene into the genome of the host cell in a dose-dependent manner.
Career Highlights
Irma Querques is affiliated with the European Molecular Biology Laboratory, where she continues to advance her research in gene delivery technologies. Her innovative work has positioned her as a key figure in the field, contributing to the development of new therapeutic strategies.
Collaborations
Irma collaborates with notable colleagues, including Orsolya Barabas and Cecilia Ines Zuliani. Their combined expertise enhances the research efforts at the European Molecular Biology Laboratory.
Conclusion
Irma Querques is a trailblazer in the field of gene delivery, with her patents paving the way for advancements in therapeutic applications. Her contributions are vital for the future of genetic engineering and medicine.